Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.

ABSTRACT: The ability of zebrafish to heal their heart after injury makes them an attractive model for investigating the mechanisms governing the regenerative process. In this study, we show that the gene cellular communication network factor 2a (ccn2a), previously known as ctgfa, is induced in endocardial cells in the injured tissue and regulates CM proliferation and repopulation of the damaged tissue. We find that, whereas in wild-type animals, CMs track along the newly formed blood vessels that revascularize the injured tissue, in ccn2a mutants CM proliferation and repopulation are disrupted, despite apparently unaffected revascularization. In addition, we find that ccn2a overexpression enhances CM proliferation and improves the resolution of transient collagen

SUBMITTER: Mukherjee D 

PROVIDER: S-EPMC7847265 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature