Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development.

ABSTRACT: The control of size and shape is an important part of regulatory process during organogenesis. Tooth formation is a highly complex process that fine-tunes the size and shape of the tooth, which are crucial for its physiological functions. Each tooth consists of a crown and one or more roots. Despite comprehensive knowledge of the mechanism that regulates early tooth crown development, we have limited understanding of the mechanism regulating root patterning and size during development. Here, we show that Ror2-mediated non-canonical Wnt signaling in the dental mesenchyme plays a crucial role in cell proliferation, and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation. Importantly, activatio

SUBMITTER: Ma Y 

PROVIDER: S-EPMC7847279 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature