Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality.

ABSTRACT: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people and crippled economies worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for this pandemic has triggered avid research on its pathobiology to better understand the pathophysiology of COVID-19. In the absence of approved antiviral therapeutic strategies or vaccine platforms capable of effectively targeting this global threat, the hunt for effective therapeutics has led to many candidates being actively evaluated for their efficacy in controlling or preventing COVID-19. In this review, we gathered current evidence on the innate nucleic acid-sensing pathways expected to be elicited by SARS-CoV-2 and the immune evasion mechanisms they have developed to promote viral replicatio

SUBMITTER: Mdkhana B 

PROVIDER: S-EPMC7847386 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature