Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes.

ABSTRACT:

Background

Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone for public health control of the pandemic and vaccine development. However, current evidence is rather based on limited measurements, losing sight of the temporal pattern of these changes.

Methods

We conducted a longitudinal analysis on a prospective cohort of COVID-19 patients followed up for >6 months. Neutralizing activity was evaluated using HIV reporter pseudoviruses expressing SARS-CoV-2 S protein. IgG antibody titer was evaluated by ELISA against the S2 subunit, the receptor binding domain (RBD), and the nucleoprotein (NP). Statistical analyses were carried out using mixed-effects models.

Findings

We found that individuals with mild or asymptomatic infection experienced an i

SUBMITTER: Pradenas E 

PROVIDER: S-EPMC7847406 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature