Ontology highlight
ABSTRACT:
SUBMITTER: Sievers P
PROVIDER: S-EPMC7847462 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Sievers Philipp P Sill Martin M Blume Christina C Tauziede-Espariat Arnault A Schrimpf Daniel D Stichel Damian D Reuss David E DE Dogan Helin H Hartmann Christian C Mawrin Christian C Hasselblatt Martin M Stummer Walter W Schick Uta U Hench Jürgen J Frank Stephan S Ketter Ralf R Schweizer Leonille L Schittenhelm Jens J Puget Stéphanie S Brandner Sebastian S Jaunmuktane Zane Z Küsters Benno B Abdullaev Zied Z Pekmezci Melike M Snuderl Matija M Ratliff Miriam M Herold-Mende Christel C Unterberg Andreas A Aldape Kenneth K Ellison David W DW Wesseling Pieter P Reifenberger Guido G Wick Wolfgang W Perry Arie A Varlet Pascale P Pfister Stefan M SM Jones David T W DTW von Deimling Andreas A Sahm Felix F
Acta neuropathologica 20201214 2
Clear cell meningioma represents an uncommon variant of meningioma that typically affects children and young adults. Although an enrichment of loss-of-function mutations in the SMARCE1 gene has been reported for this subtype, comprehensive molecular investigations are lacking. Here we describe a molecularly distinct subset of tumors (n = 31), initially identified through genome-wide DNA methylation screening among a cohort of 3093 meningiomas, of which most were diagnosed histologically as clear ...[more]