Identification of key miRNA-gene pairs in gastric cancer through integrated analysis of mRNA and miRNA microarray.

ABSTRACT: Nowadays, the current bioinformatic methods have been increasingly applied in the field of oncological research. In this study, we expect a better understanding of the molecular mechanism of gastric cancer from the bioinformatic methods. By systematically addressing the differential expression of microRNAs (miRNAs) and mRNAs between gastric cancer specimens and normal gastric specimens with the application of bioinformatics tools, A total of 206 DEGs and 38 DEMs were identified. The Gene Ontology (GO) analysis of Annotation, Visualization and Integrated Discovery (DAVID) database revealed that the differentially expressed genes (DEGs) were significantly enriched in biological process, molecular function and cellular component, while Kyoto Encyclopedia of Genes and Genomes (KEGG) database s

SUBMITTER: Zhu T 

PROVIDER: S-EPMC7847513 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature