Changes of blood-brain-barrier function and transfer of amyloid beta in rats with collagen-induced arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is characterized by synovial inflammation, cartilage damage, and systemic inflammation. RA is also associated with the occurrence of neuroinflammation and neurodegenerative diseases. In this study, the impacts of RA on the function of the blood-brain barrier (BBB) and the disposition of amyloid beta (Aβ), including BBB transport and peripheral clearance of Aβ, were investigated in rats with collagen-induced arthritis (CIA), an animal model with similarity to clinical and pathological features of human RA.

Methods

CIA was induced in female Lewis rats. In addition to neuroinflammation, the integrity and function of the BBB were examined. The expression of Aβ-transporting proteins at brain blood vessels was measured. Blood-to-brain influx an

SUBMITTER: Lai PH 

PROVIDER: S-EPMC7847579 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature