Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a clinicopathologically heterogeneous chronic autoimmune disorder affecting different organs and tissues. It has been reported that there is an increasing rate of SLE incidence among Iranian population. Moreover, the Iranian SLE patients have more severe clinical manifestations compared with other countries. Therefore, it is required to introduce novel methods for the early detection of SLE in this population. Various environmental and genetic factors are involved in SLE progression.

Main body

In present review we have summarized all of the reported genes which have been associated with clinicopathological features of SLE among Iranian patients.

Conclusions

Apart from the reported cytokines and chemokines, it was intere

SUBMITTER: Gachpazan M 

PROVIDER: S-EPMC7847600 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature