ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC7847666 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.
Chen Xiaozheng X Gao Aiqin A Zhang Fang F Yang Zijiang Z Wang Shuyun S Fang Yuying Y Li Juan J Wang Jingnan J Shi Wenjing W Wang Linlin L Zheng Yan Y Sun Yuping Y
Theranostics 20210119 7
<b>Rationale:</b> Immune checkpoint inhibitors (ICIs) against the PD-1/PD-L1 pathway showed limited success in non-small cell lung cancer (NSCLC) patients, especially in those with activating epidermal growth factor receptor (EGFR) mutations. Elucidation of the mechanisms underlying EGFR-mediated tumor immune escape and the development of effective immune therapeutics are urgently needed. Immunoglobulin-like transcript (ILT) 4, a crucial immunosuppressive molecule initially identified in myeloid ...[more]
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