Correlation of interleukin-6 and C-reactive protein levels in plasma with the stage and differentiation of colorectal cancer: A cross-sectional study in East Indonesia.

ABSTRACT:

Introduction

Tumors most often develop due to inflammatory factors, including inflammatory cells that produce cytokines and cytotoxic mediators that can stimulate malignant transformation. Knowing that interleukin-6 (IL-6) and C-reactive protein (CRP) factor into the development of colorectal cancer (CRC), we aimed to assess IL-6 and CRP's relationship with the stage and differentiation of CRC.

Methods

In a sample of 46 patients with CRC, as confirmed by histopathological examination, plasma levels of IL-6 and CRP were measured from peripheral venous blood samples before surgery and examined using enzyme-linked immunosorbent assay.

Results

Most patients were male (63.0%) and at least 50 years old (73.9%). A positive correlation emerged between stage of CRC and both pl

SUBMITTER: Hidayat F 

PROVIDER: S-EPMC7847822 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature