Population Pharmacokinetics and Dose Optimization of Ganciclovir in Critically Ill Children.

ABSTRACT: Objective: The present study aims to establish a population pharmacokinetic model of ganciclovir and optimize the dosing regimen in critically ill children suffering from cytomegalovirus related disease. Methods: A total of 104 children were included in the study. The population pharmacokinetic model was developed using the Phoenix NLME program. The final model was validated by diagnostic plots, nonparametric bootstrap, visual predictive check, and normalized prediction distribution errors. To further evaluate and optimize the dosing regimens, Monte Carlo simulations were performed. Moreover, the possible association between systemic exposure and hematological toxicity were also monitored in the assessment of adverse events. Results: The ganciclovir pharmacokinetics co

SUBMITTER: Li S 

PROVIDER: S-EPMC7847843 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature