Real-time fMRI neurofeedback amygdala training may influence kynurenine pathway metabolism in major depressive disorder.

ABSTRACT: Real-time fMRI neurofeedback (rtfMRI-nf) left amygdala (LA) training is a promising intervention for major depressive disorder (MDD). We have previously proposed that rtfMRI-nf LA training may reverse depression-associated regional impairments in neuroplasticity and restore information flow within emotion-regulating neural circuits. Inflammatory cytokines as well as the neuroactive metabolites of an immunoregulatory pathway, i.e. the kynurenine pathway (KP), have previously been implicated in neuroplasticity. Therefore, in this proof-of-principle study, we investigated the association between rtfMRI-nf LA training and circulating inflammatory mediators and KP metabolites. Based on our previous work, the primary variable of interest was the ratio of the NMDA-receptor antagonist, kynurenic a

SUBMITTER: Tsuchiyagaito A 

PROVIDER: S-EPMC7847971 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature