Memantine hydrochloride: a drug to be repurposed against Chikungunya virus?

ABSTRACT:

Background

Chikungunya fever is an endemic disease caused by the Chikungunya virus (CHIKV) to which there is no vaccine or effective antiviral drug treatment so far. Our study aimed to evaluate the potential anti-CHIKV activity of memantine hydrochloride (mtnH), a drug from the class of the aminoadamantanes approved for the treatment of Alzheimer´s disease, as a possible drug to be repurposed to the treatment of Chikungunya fever.

Methods

MtnH antiviral activity against CHIKV was determined by infecting BHK-21 cells with CHIKV-nanoluc, a virus carrying the marker nanoluciferase reporter, in the presence or absence of mtnH at concentrations ranging from 500 to 1.45 µM. The effective concentration of 50% inhibition (EC₅₀) was calculated. Cell viability assay (determ

SUBMITTER: Pereira AKDS 

PROVIDER: S-EPMC7848042 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature