Age-Associated Differences of Modules and Hubs in Brain Functional Networks.

ABSTRACT: Healthy aging is usually accompanied by changes in the functional modular organization of the human brain, which may result in the decline of cognition and underlying brain dysfunction. However, the relationship between age-related brain functional modular structure differences and cognition remain debatable. In this study, we investigated the age-associated differences of modules and hubs from young, middle and old age groups, using resting-state fMRI data from a large cross-sectional adulthood sample. We first divided the subjects into three age groups and constructed an individual-level network for each subject. Subsequently, a module-guided group-level network construction method was applied to form a weighted network for each group from which functional modules were detected. The intr

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7848126 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature