Dynamic RNA Regulation in the Brain Underlies Physiological Plasticity in a Hibernating Mammal.

ABSTRACT: Hibernation is a physiological and behavioral phenotype that minimizes energy expenditure. Hibernators cycle between profound depression and rapid hyperactivation of multiple physiological processes, challenging our concept of mammalian homeostasis. How the hibernator orchestrates and survives these extremes while maintaining cell to organismal viability is unknown. Here, we enhance the genome integrity and annotation of a model hibernator, the 13-lined ground squirrel. Our new assembly brings this genome to near chromosome-level contiguity and adds thousands of previously unannotated genes. These new genomic resources were used to identify 6,505 hibernation-related, differentially-expressed and processed transcripts using RNA-seq data from three brain regions in animals whose physiologica

SUBMITTER: Fu R 

PROVIDER: S-EPMC7848201 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature