Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling.

ABSTRACT:

Background

Eradication of intramucosal Escherichia coli correlates with remission of periodic acid-Schiff-positive E coli-associated granulomatous colitis (GC). Treatment failures attributed to multidrug resistant (MDR) bacteria necessitate alternative approaches.

Hypothesis/objectives

Determine clinical outcome of E coli-associated GC in dogs treated based on antimicrobial susceptibility profiling and characterize E coli phylogeny and resistance mechanisms.

Animals

Twenty Boxers and 4 French Bulldogs with E coli-associated GC.

Methods

Culture, antimicrobial susceptibility profiling, and molecular characterization of E coli were performed and response to treatment was evaluated.

Results

Initial biopsy sample culture yielded fluoroquinolone-sensitive (FQ-

SUBMITTER: Manchester AC 

PROVIDER: S-EPMC7848323 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature