High serum creatinine concentration is associated with metabolic perturbations in dogs.

ABSTRACT:

Background

The kidneys have many essential metabolic functions, and metabolic disturbances during decreased renal function have not been studied extensively.

Objectives

To identify metabolic changes in blood samples with increased serum creatinine concentration, indicating decreased glomerular filtration.

Animals

Clinical samples analyzed using a nuclear magnetic resonance (NMR) based metabolomics platform. The case group consisted of 23 samples with serum creatinine concentration >125 μmol/L, and the control group of 873 samples with serum creatinine concentration within the reference interval.

Methods

Biomarker association with increased serum creatinine concentration was evaluated utilizing 3 statistical approaches: Wilcoxon rank-sum test, logistic regressio

SUBMITTER: Ottka C 

PROVIDER: S-EPMC7848334 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature