Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model.

ABSTRACT: Stem cells offer the basis for the promotion of robust new therapeutic approaches for a variety of human disorders. There are still many limitations to be overcome before clinical therapeutic application, including a better understanding of the mechanism by which stem cell therapies may lead to enhanced recovery. In vitro investigations are necessary to dissect the mechanisms involved and to support the potential development in stem cell-based therapies. In spite of growing interest in human amniotic fluid stem cells, not much is known about the characteristics of their secretome and regarding the potential neuroprotective mechanism in different pathologies, including stroke. To get more insight on amniotic fluid cells therapeutic potential, signal transduction pathways activated by human

SUBMITTER: Castelli V 

PROVIDER: S-EPMC7848376 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature