Major differences in clinical presentation, diagnosis and management of men and women with autosomal inherited bleeding disorders.

ABSTRACT:

Background

In recent years, more awareness is raised about sex-specific dilemmas in inherited bleeding disorders. However, no large studies have been performed to assess differences in diagnosis, bleeding phenotype and management of men and women with bleeding disorders. Therefore, we investigated sex differences in a large cohort of well-defined patients with autosomal inherited bleeding disorders (von Willebrand disease (VWD), rare bleeding disorders (RBDs) and congenital platelet defects (CPDs)).

Methods

We included patients from three nationwide cross-sectional studies on VWD, RBDs and CPDs in the Netherlands, respectively the WiN, RBiN and TiN study. In all studies a bleeding score (BS) was obtained, and patients filled in an extensive questionnaire on the management an

SUBMITTER: Atiq F 

PROVIDER: S-EPMC7848767 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature