Systemic transcriptome comparison between early- And late-onset pre-eclampsia shows distinct pathology and novel biomarkers.

ABSTRACT:

Objectives

Pre-eclampsia is a leading cause of morbidity and mortality during pregnancy. Although the two forms of this disorder, early- (EOPE) and late-onset of pre-eclampsia (LOPE) are different, the underlying pathology remains elusive. We aim to unravel the difference and to identify novel biomarkers for EOPE and LOPE.

Materials and methods

A complete comparison of both placental and peripheral blood transcriptomes was performed to investigate the pathology of pre-eclampsia. Single-cell transcriptomics of the maternal-fetal interface were integrated to identify novel biomarkers for EOPE and LOPE which were further verified at protein or mRNA level in patients.

Results

We found that the transcriptomes of placentae from EOPE, but not LOPE, were significantly differe

SUBMITTER: Guo F 

PROVIDER: S-EPMC7848957 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature