Opioid therapy duration before naldemedine treatment is a significant independent risk of diarrhea: a retrospective cohort study.

ABSTRACT:

Background

The most common adverse event (AE) associated with opioid analgesics is opioid-induced constipation (OIC). Naldemedine (NAL) is widely used for the treatment of OIC. However, diarrhea has been reported as the most common treatment-emergent AE of NAL, and little is known about the risk factors associated with the development of diarrhea during NAL administration. This study examined the risk factors for NAL-induced diarrhea via a retrospective chart review of hospitalized patients.

Methods

The data of 101 hospitalized adult patients who received NAL for the first time for the treatment of OIC at Mie University Hospital between June 2017 and December 2018 were extracted from electronic medical records. According to the inclusion and exclusion criteria, 70 of the 101

SUBMITTER: Okamoto A 

PROVIDER: S-EPMC7849155 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature