NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation.

ABSTRACT:

Objectives

NLRP3 inflammasome is a critical part of the innate immune system and plays an important role in a variety of inflammatory diseases. However, the effects of NLRP3 inflammasome on periodontitis have not been fully studied.

Materials and methods

We used ligature-induced periodontitis models of NLRP3 knockout mice (NLRP3^KO ) and their wildtype (WT) littermates to compare their alveolar bone phenotypes. We further used Lysm-Cre/Rosa^nTnG mouse to trace the changes of Lysm-Cre⁺ osteoclast precursors in ligature-induced periodontitis with or without MCC950 treatment. At last, we explored MCC950 as a potential drug for the treatment of periodontitis in vivo and in vitro.

Results

Here, we showed that the number of osteoclast precurso

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7849172 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature