Profiling neural editomes reveals a molecular mechanism to regulate RNA editing during development.

ABSTRACT: Adenosine (A) to inosine (I) RNA editing contributes to transcript diversity and modulates gene expression in a dynamic, cell type-specific manner. During mammalian brain development, editing of specific adenosines increases, whereas the expression of A-to-I editing enzymes remains unchanged, suggesting molecular mechanisms that mediate spatiotemporal regulation of RNA editing exist. Herein, by using a combination of biochemical and genomic approaches, we uncover a molecular mechanism that regulates RNA editing in a neural- and development-specific manner. Comparing editomes during development led to the identification of neural transcripts that were edited only in one life stage. The stage-specific editing is largely regulated by differential gene expression during neural development. Pro

SUBMITTER: Rajendren S 

PROVIDER: S-EPMC7849389 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature