Post-transcriptional circadian regulation in macrophages organizes temporally distinct immunometabolic states.

ABSTRACT: Our core timekeeping mechanism, the circadian clock, plays a vital role in immunity. Although the mechanics of circadian control over the immune response is generally explained by transcriptional activation or repression derived from this clock's transcription-translation negative-feedback loop, research suggests that some regulation occurs beyond transcriptional activity. We comprehensively profiled the transcriptome and proteome of murine bone marrow-derived macrophages and found that only 15% of the circadian proteome had corresponding oscillating mRNA, suggesting post-transcriptional regulation influences macrophage clock regulatory output to a greater extent than any other tissue previously profiled. This regulation may be explained by the robust temporal enrichment we identified for

SUBMITTER: Collins EJ 

PROVIDER: S-EPMC7849412 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature