Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysis.

ABSTRACT:

Background

The global death toll from coronavirus disease 2019 (COVID-19) has exceeded 2 million, and treatments to decrease mortality are needed urgently.

Objectives

To examine the probabilities of a clinically meaningful reduction in mortality for remdesivir and systemic corticosteroids.

Design, setting and participants

This was a probabilistic re-analysis of clinical trial data for corticosteroids and remdesivir in the treatment of hospitalized patients with COVID-19 using a Bayesian random effects meta-analytic approach. Studies were identified from existing meta-analyses performed by the World Health Organization.

Main outcomes and measures

Posterior probabilities of an absolute decrease in mortality compared with control patients, by subgroups based on ox

SUBMITTER: Lee TC 

PROVIDER: S-EPMC7849442 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature