Transcriptome analysis reveals liver metabolism programming in kids from nutritional restricted goats during mid-gestation.

ABSTRACT:

Background

Maternal nutrient restriction during pregnancy causes a metabolic disorder that threatens the offspring's health in humans and animals. However, the molecular mechanism of how undernutrition affecting hepatic metabolism of fetal or postnatal offspring is still unclear. We aimed to investigate transcriptomic changes of fetal livers in response to maternal malnutrition in goats during mid-gestation and to explore whether these changes would disappear when the nutrition was recovered to normal level during mid-gestation using goats (Capra hircus) as the experimental animals.

Methods

Fifty-three pregnant goats were subjected to a control (100% of the maintenance requirements, CON) or a restricted (60% of the maintenance requirements on day 45 to day 100 of gest

SUBMITTER: Yang C 

PROVIDER: S-EPMC7849524 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature