Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow.

ABSTRACT:

Key points

Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that regulates intraocular pressure through the control of aqueous humour drainage. Its dysfunction underlies the progression of glaucoma but neither the mechanisms through which TM cells sense pressure nor their role in aqueous humour outflow are understood at the molecular level. We identified the Piezo1 channel as a key TM transducer of tensile stretch, shear flow and pressure. Its activation resulted in intracellular signals that altered organization of the cytoskeleton and cell-extracellular matrix contacts and modulated the trabecular component of aqueous outflow whereas another channel, TRPV4, mediated a delayed mechanoresponse. This study helps elucidate basic mechanotransduction properties t

SUBMITTER: Yarishkin O 

PROVIDER: S-EPMC7849624 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature