Approaches to inhibiting oncogenic K-Ras.
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ABSTRACT:
SUBMITTER: Gorfe AA
PROVIDER: S-EPMC7849769 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Approaches to inhibiting oncogenic K-Ras.
Gorfe Alemayehu A AA Cho Kwang-Jin KJ
Small GTPases 20190822 2
Activating somatic K-Ras mutations are associated with >15% all human tumors and up to 90% of specific tumor types such as pancreatic cancer. Successfully inhibiting abnormal K-Ras signaling would therefore be a game changer in cancer therapy. However, K-Ras has long been considered an undruggable target for various reasons. This view is now changing by the discovery of allosteric inhibitors that directly target K-Ras and inhibit its functions, and by the identification of new mechanisms to disl ...[more]
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