YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus.

ABSTRACT: We previously reported that disruption of the yjbI gene reduced virulence of Staphylococcus aureus. In this study, we found virulence in both silkworms and mice was restored by introducing the yjbH gene but not the yjbI gene to both yjbI and yjbH genes-disrupted mutants, suggesting that yjbH, the gene downstream to the yjbI gene in a two-gene operon-yjbIH, is responsible for this phenomenon. We further observed a decrease in various surface-associated proteins and changes in cell envelope glycostructures in the mutants. RNA-seq analysis revealed that disruption of the yjbI and the yjbH genes resulted in differential expression of a broad range of genes, notably, significant downregulation of genes involved in viru

SUBMITTER: Paudel A 

PROVIDER: S-EPMC7849776 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature