Repositioning Drugs on Human Influenza A Viruses Based on a Novel Nuclear Norm Minimization Method.

ABSTRACT: Influenza A viruses, especially H3N2 and H1N1 subtypes, are viruses that often spread among humans and cause influenza pandemic. There have been several big influenza pandemics that have caused millions of human deaths in history, and the threat of influenza viruses to public health is still serious nowadays due to the frequent antigenic drift and antigenic shift events. However, only few effective anti-flu drugs have been developed to date. The high development cost, long research and development time, and drug side effects are the major bottlenecks, which could be relieved by drug repositioning. In this study, we proposed a novel antiviral Drug Repositioning method based on minimizing Matrix Nuclear Norm (DRMNN). Specifically, a virus-drug correlation database consisting of 34 viruses an

SUBMITTER: Liang H 

PROVIDER: S-EPMC7849835 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature