Perspective: The Role of Human Breast-Milk Extracellular Vesicles in Child Health and Disease.

ABSTRACT: Human breast milk (HM) contains multiple bioactive substances determining its impact on children's health. Extracellular vesicles (EVs) are a heterogeneous group of secreted nanoparticles that are present in HM and may be partially responsible for its beneficial effects. The precise roles and content of EVs in HM remain largely unknown. To examine this, we performed a short narrative review on the literature focusing on HM EVs to contextualize the available data, followed by a scoping review of MEDLINE and Embase databases. We identified 424 nonduplicate citations with 19 original studies included. In this perspective, we summarize the evidence around HM EVs, highlight some theoretical considerations based on existing evidence, and provide an overview of some challenges associated with the

SUBMITTER: O'Reilly D 

PROVIDER: S-EPMC7849950 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature