Measuring cerebral perfusion with [¹¹C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

ABSTRACT: Positron emission tomography imaging of glucose hypometabolism and amyloid deposition are two well-established methods to evaluate preclinical changes in Alzheimer's disease and people with Down syndrome. However, the use of both imaging modalities may overburden participants, particularly those with intellectual disabilities and cognitive impairment. The relative tracer delivery of the [¹¹C]-Pittsburgh Compound B has been proposed as a viable surrogate for cerebral perfusion. Here, we studied the impact of amyloid pathology on perfusion changes in Down syndrome and evaluated its associations with cognitive impairment. In total, 47 adults with Down syndrome underwent the [¹¹C]-Pittsburgh Compound B imaging and structural imaging. The structural data were processed wit

SUBMITTER: Mak E 

PROVIDER: S-EPMC7849981 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature