Clinical outcomes in a large pediatric cohort of patients with ependymoma treated with proton radiotherapy.

ABSTRACT:

Background

Treatment for pediatric ependymoma includes surgical resection followed by local radiotherapy (RT). Proton RT (PRT) enables superior sparing of critical structures compared with photons, with potential to reduce late effects. We report mature outcomes, patterns of failure, and predictors of outcomes in patients treated with PRT.

Methods

One hundred fifty patients (<22 y) with World Health Organization grades II/III ependymoma were treated with PRT between January 2001 and January 2019 at Massachusetts General Hospital. Demographic, tumor, and treatment-related characteristics were analyzed. Event-free survival (EFS), overall survival (OS), and local control (LC) were assessed.

Results

Median follow-up was 6.5 years. EFS, OS, and LC for the intracranial coho

SUBMITTER: Patteson BE 

PROVIDER: S-EPMC7849993 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature