Elevated free secretory component in early rheumatoid arthritis and prior to arthritis development in patients at increased risk.

ABSTRACT:

Objectives

Considering growing evidence of mucosal involvement in RA induction, this study investigated circulating free secretory component (SC) in patients with either recent-onset RA or with ACPA and musculoskeletal pain.

Methods

Two prospective cohorts were studied: TIRA-2 comprising 452 recent-onset RA patients with 3 years of clinical and radiological follow-up, and TIRx patients (n = 104) with ACPA IgG and musculoskeletal pain followed for 290 weeks (median). Blood donors and three different chronic inflammatory diseases served as controls. Free SC was analysed by sandwich ELISA.

Results

Serum levels of free SC were significantly higher in TIRA-2 patients compared with TIRx and all control groups (P < 0.01). Among TIRx patients who subsequently developed arthri

SUBMITTER: Martinsson K 

PROVIDER: S-EPMC7850007 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature