Association between immunosuppressive therapy and course of mild interstitial lung disease in systemic sclerosis.

ABSTRACT:

Objective

Interstitial lung disease (ILD) is a leading cause of mortality in SSc. Little is known about the benefits of immunosuppressive drugs in mild ILD. Our aim was to determine whether use of CYC or MMF was associated with an improved ILD course in patients with normal or mildly impaired lung function.

Methods

A retrospective cohort of SSc subjects with ILD, disease duration below seven years and no exposure to CYC or MMF prior to the baseline visit was constructed from the Canadian Scleroderma Research Group registry. Subjects were categorized as having mild ILD if baseline forced vital capacity (FVC % predicted) was >85%. The primary exposure was any use of CYC or MMF at the baseline visit. FVC at one year was compared between exposed and unexposed subjects, using mul

SUBMITTER: Hoa S 

PROVIDER: S-EPMC7850061 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature