NF1 optic pathway glioma: analyzing risk factors for visual outcome and indications to treat.

ABSTRACT:

Background

The aim of the project was to identify risk factors associated with visual progression and treatment indications in pediatric patients with neurofibromatosis type 1 associated optic pathway glioma (NF1-OPG).

Methods

A multidisciplinary expert group consisting of ophthalmologists, pediatric neuro-oncologists, neurofibromatosis specialists, and neuro-radiologists involved in therapy trials assembled a cohort of children with NF1-OPG from 6 European countries with complete clinical, imaging, and visual outcome datasets. Using methods developed during a consensus workshop, visual and imaging data were reviewed by the expert team and analyzed to identify associations between factors at diagnosis with visual and imaging outcomes.

Results

Eighty-three patients (37

SUBMITTER: Azizi AA 

PROVIDER: S-EPMC7850076 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature