Derivation of an angiographically based classification system in Takayasu's arteritis: an observational study from India and North America.

ABSTRACT:

Objectives

To develop and replicate, using data-driven methods, a novel classification system in Takayasu's arteritis based on distribution of arterial lesions.

Methods

Patients were included from four international cohorts at major academic centres: India (Christian Medical College Vellore); North America (National Institutes of Health, Vasculitis Clinical Research Consortium and Cleveland Clinic Foundation). All patients underwent whole-body angiography of the aorta and branch vessels, with categorization of arterial damage (stenosis, occlusion or aneurysm) in 13 territories. K-means cluster analysis was performed to identify subgroups of patients based on pattern of angiographic involvement. Cluster groups were identified in the Indian cohort and independently replicated

SUBMITTER: Goel R 

PROVIDER: S-EPMC7850097 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature