An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures.

ABSTRACT:

Motivation

Recapitulating aspects of human organ functions using in vitro (e.g. plates, transwells, etc.), in vivo (e.g. mouse, rat, etc.), or ex vivo (e.g. organ chips, 3D systems, etc.) organ models is of paramount importance for drug discovery and precision medicine. It will allow us to identify potential side effects and test the effectiveness of new therapeutic approaches early in their design phase, and will inform the development of better disease models. Developing mathematical methods to reliably compare the 'distance/similarity' of organ models from/to the real human organ they represent is an understudied problem with important applications in biomedicine and tissue engineering.

Results

We introduce the Transcriptomic Signature Distance (TSD), an information-theor

SUBMITTER: Manatakis DV 

PROVIDER: S-EPMC7850114 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature