Systematic literature review of non-topical treatments for early, untreated (systemic therapy naive) psoriatic disease: a GRAPPA initiative.

ABSTRACT:

Background

Psoriatic disease (PsD) is a complex systemic disorder with cutaneous and musculoskeletal manifestations. Current evidence on pharmacological interventions, effective across the spectrum of clinical manifestations of early, systemic treatment-naïve PsD, is limited. This review aims to appraise such evidence.

Methods

This systematic review examined seven patient-intervention-comparator-outcome research questions to address the efficacy of the interventions on the following: across the spectrum of clinical manifestations PsD activity; peripheral arthritis; dactylitis; spondylitis; enthesitis; skin; and nails. Early PsD was defined as a disease duration of ≤2 years, except for studies investigating outcomes restricted to the skin. Eligible references were clinical tr

SUBMITTER: De Marco G 

PROVIDER: S-EPMC7850142 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature