Inhaled nitric oxide and acute kidney injury risk: a meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

There are conflicting results as to the effect of inhaled nitric oxide (iNO) therapy on the risk of acute kidney injury (AKI). The aim of this study was to perform a meta-analysis to assess the updated data.

Methods

We systematically searched Web of Science, the Cochrane Library, Wanfang, and PubMed for relevant randomized control trials between database inception and 9/07/2020. Relative risks (RRs) with 95% confidence intervals (CIs) predicting the risk of AKI were extracted to obtain summary estimates using fixed-effects models. The Trim and Fill method was used to evaluate the sensitivity of the results and adjust for publication bias in meta-analysis.

Results

15 randomized controlled studies from 14 articles involving 1853 patients were included in the stu

SUBMITTER: Wang J 

PROVIDER: S-EPMC7850389 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature