Estimating and interpreting secondary attack risk: Binomial considered biased.

ABSTRACT: The household secondary attack risk (SAR), often called the secondary attack rate or secondary infection risk, is the probability of infectious contact from an infectious household member A to a given household member B, where we define infectious contact to be a contact sufficient to infect B if he or she is susceptible. Estimation of the SAR is an important part of understanding and controlling the transmission of infectious diseases. In practice, it is most often estimated using binomial models such as logistic regression, which implicitly attribute all secondary infections in a household to the primary case. In the simplest case, the number of secondary infections in a household with m susceptibles and a single primary case is modeled as a binomial(m, p) random variable where p is the

SUBMITTER: Sharker Y 

PROVIDER: S-EPMC7850487 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature