Drug resistance gene mutations and treatment outcomes in MDR-TB: A prospective study in Eastern China.

ABSTRACT:

Background

Multidrug-resistant tuberculosis (MDR-TB) poses a serious challenge to TB control. It is of great value to search for drug resistance mutation sites and explore the roles that they play in the diagnosis and prognosis of MDR-TB.

Methods

We consecutively enrolled MDR-TB patients from five cities in Jiangsu Province, China, between January 2013 and December 2014. Drug susceptibility tests of rifampin, isoniazid, ofloxacin, and kanamycin were routinely performed by proportion methods on Lowenstein-Jensen (LJ) medium. Drug resistance-related genes were sequenced, and the consistency of genetic mutations and phenotypic resistance was compared. The association between mutations and treatment outcomes was expressed as odds ratios (ORs) and 95% confidence intervals (CIs).<

SUBMITTER: Liu Q 

PROVIDER: S-EPMC7850501 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature