The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32.

ABSTRACT:

Background

Metformin has been associated with lower breast cancer (BC) risk and improved outcomes in observational studies. Multiple biologic mechanisms have been proposed, including a recent report of altered sex hormones. We evaluated the effect of metformin on sex hormones in MA.32, a phase III trial of nondiabetic BC subjects who were randomly assigned to metformin or placebo.

Methods

We studied the subgroup of postmenopausal hormone receptor-negative BC subjects not receiving endocrine treatment who provided fasting blood at baseline and at 6 months after being randomly assigned. Sex hormone-binding globulin, bioavailable testosterone, and estradiol levels were assayed using electrochemiluminescence immunoassay. Change from baseline to 6 months between study arms was co

SUBMITTER: Pimentel I 

PROVIDER: S-EPMC7850529 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature