Development and validation of an alternative ankylosing spondylitis disease activity score when patient global assessment is unavailable.

ABSTRACT:

Objective

To develop an alternative Ankylosing Spondylitis Disease Activity Score (ASDAS) to be used in research settings in axial SpA (axSpA) when Patient Global Assessment (PGA) is unavailable in databases.

Methods

Longitudinal data from four axSpA cohorts and two randomized controlled trials were combined. Observations were randomly split in a development (N = 1026) and a validation cohort (N = 1059). Substitutes of PGA by BASDAI total score, single or combined individual BASDAI questions, and a constant value, were established in the development cohort. Conversion factors for each substitute were defined by Generalized Estimating Equations, obtaining seven 'alternative' formulae. Validation was performed in the validation cohort according to the OMERACT filter, taking in

SUBMITTER: Ortolan A 

PROVIDER: S-EPMC7850538 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature