All-Cause and Cardiovascular Disease Mortality Among Breast Cancer Survivors in CLUE II, a Long-Standing Community-Based Cohort.

ABSTRACT:

Background

There is growing evidence that breast cancer survivors have higher cardiovascular disease (CVD) mortality relative to the general population. Information on temporal patterns for all-cause and CVD mortality among breast cancer survivors relative to cancer-free women is limited.

Methods

All-cause and CVD-related mortality were compared in 628 women with breast cancer and 3140 age-matched cancer-free women within CLUE II, a prospective cohort. We calculated adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression for all-cause mortality, and Fine and Gray models for CVD-related mortality to account for competing risks.

Results

Over 25 years of follow-up, 916 deaths occurred (249 CVD related). Breast cancer surv

SUBMITTER: Ramin C 

PROVIDER: S-EPMC7850550 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature