CYP2C9 Variations and Their Pharmacogenetic Implications Among Diverse South Asian Populations.

ABSTRACT:

Introduction

Allelic frequency distribution of drug metabolizing enzyme genes among populations is important to identify risk groups for adverse drug reaction and to select representative populations for clinical trials. Although India emerged as an important hub for clinical trials, information about the pharmacogenetic diversity for this region is still lacking. Here, we investigated genetic diversity of cytochrome-P450-2C9 (CYP2C9) gene which metabolizes wide range of drugs and is highly expressed in the human liver.

Methods

In total, 1278 individuals from 36 diverse Indian populations, 210 individuals from in-house data-repository and 489 other South Asian samples from the 1000 Genomes Project were selected. Variants observed in CYP2C9 gene were subjected t

SUBMITTER: Nizamuddin S 

PROVIDER: S-EPMC7850565 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature