Cardiorespiratory fitness and hippocampal volume predict faster episodic associative learning in older adults.

ABSTRACT: Declining episodic memory is common among otherwise healthy older adults, in part due to negative effects of aging on hippocampal circuits. However, there is significant variability between individuals in severity of aging effects on the hippocampus and subsequent memory decline. Importantly, variability may be influenced by modifiable protective physiological factors such as cardiorespiratory fitness (CRF). More research is needed to better understand which aspects of cognition that decline with aging benefit most from CRF. The current study evaluated the relation of CRF with learning rate on the episodic associative learning (EAL) task, a task designed specifically to target hippocampal-dependent relational binding and to evaluate learning with repeated occurrences. Results show higher C

SUBMITTER: Cole RC 

PROVIDER: S-EPMC7850579 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature