Is Cohort Representativeness Passe? Poststratified Associations of Lifestyle Risk Factors with Mortality in the UK Biobank.

ABSTRACT:

Background

The UK Biobank (UKB) has been used widely to examine associations between lifestyle risk factors and mortality outcomes. It is unknown whether the extremely low UKB response rate (5.5%) and lack of representativeness materially affects the magnitude and direction of effect estimates.

Methods

We used poststratification to match the UKB sample to the target population in terms of sociodemographic characteristics and prevalence of lifestyle risk factors (physical inactivity, alcohol intake, smoking, and poor diet). We compared unweighted and poststratified associations between each lifestyle risk factor and a lifestyle index score with all-cause, cardiovascular disease (CVD), and cancer mortality. We also calculated the unweighted to poststratified ratio of HR (RHR)

SUBMITTER: Stamatakis E 

PROVIDER: S-EPMC7850587 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature