Sporadic late-onset nemaline myopathy: a case report of a treatable cause of cardiac failure.

ABSTRACT:

Background

Sporadic late-onset nemaline myopathy (SLONM) is a rare, acquired, adult-onset myopathy, characterized by proximal muscle weakness and the pathognomonic feature of nemaline rods in muscle fibres. Sporadic late-onset nemaline myopathy is associated with cardiac pathology in case reports and small case series, but the severity of cardiac disease is generally mild and rarely requires specific treatment. This case report describes severe heart failure as an early feature of SLONM, which responded to specific treatments, and highlights SLONM as a potentially reversible cause of heart failure.

Case summary

A 65-year-old woman presented with progressive muscle weakness and a dramatic loss of muscle bulk in her thighs, followed by progressive effort breathlessness over an

SUBMITTER: Turnquist C 

PROVIDER: S-EPMC7850604 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature