CCT6A, a novel prognostic biomarker for Ewing sarcoma.

ABSTRACT:

Background

Ewing sarcoma (ES), the second most prevalent bone malignant tumor has no widely known prognostic biomarker. Earlier studies have suggested that chaperonin containing TCP1 complex 6A (CCT6A), which encodes a molecular protein chaperone, is involved in the pathogenesis of many cancers. However, there are no known reports providing clear evidence of its role in ES pathogenesis.

Methods

We performed a bioinformatic analysis of 32 ES specimens from the GSE17618 dataset concentrating on the differences in gene expression, OS, event-free survival (EFS) in the different subgroups. Immunohistochemical studies were also performed to identify the expression levels of selected genes in ES and immediate paracancerous tissues.

Results

After 3 screenings, CCT6A was ident

SUBMITTER: Jiang J 

PROVIDER: S-EPMC7850773 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature